Life Extension Circadian Sleep

Health benefits at a glance:

Your sleep-wake cycle is governed by your circadian rhythm, also known as your body clock. When the circadian rhythm is brought out of balance you are not only having trouble sleeping. A circadian balance which is “out of tune” for longer periods of time can also affect your overall health negatively because good sleep and a healthy circadian rhythm are so essential to good health. Circadian Sleep is a novel formula that uses a specially developed mix of melatonin and citrus peel extract to support normal circadian rhythms that help you sleep well and promote whole body health.

Why it works:

Your body clock (circadian rhythm) is best known for being an internal timekeeper that regulates your sleep-wake cycle. However, few people know that there are actually two circadian rhythms: a central rhythm and a peripheral rhythm. The central circadian rhythm regulates sleep and other body functions such as temperature in accordance with the time of the day. In turn, the peripheral circadian rhythm regulates essential processes in your organs such as your heart rate, body temperature hormone release, blood pressure, liver and kidney function, pancreatic function and more [4-6].

However, aging, a hectic lifestyle and many other factors can contribute to the disruption of both of your circadian cycles. Over time this can affect your overall health [7-9].

Circadian Sleep has been developed to help restore and reset both types of circadian rhythms, using two ingredients. While MicroActive® Melatonin targets the central body clock in your brain, Nobiletin citrus peel extract promotes a healthy peripheral circadian rhythm in your organs.

By using these two ingredients, the Circadian Sleep formula not only promotes a body clock (circadian rhythm) in balance. It also supports healthy sleep-wake cycles, promotes brain health and contributes to overall health.

The science behind the product:

Interestingly, almost all cells in your body have their own circadian rhythm. The cellular circadian rhythm is also known as the peripheral circadian clock. Its pace is being set by the central circadian rhythm because it regulates your sleep-wake cycles [1].

Melatonin is known as the sleep hormone because it helps ensure that the central clock is properly regulating sleep-wake cycles. It is produced naturally in your pineal gland, primarily when you are asleep [10]. The central clock, in turn, aligns the peripheral clock which thereby also supports whole body health. When melatonin output is inadequate, it can result in sleep trouble.

Nobiletin for healthy peripheral circadian rhythms

Nobiletin (a polymethoxylated flavone) is a compound which has been derived from the peel of young citrus fruits. Nobiletin is an interesting compound in relation to circadian rhythm support because it activates a unique set of bodily regulators. It has also been shown to offer antioxidant protection to brain cells which promotes brain health. Furthermore, it also has also shown to promote a healthy inflammatory response in the body [11]. 

Pre-clinical studies have shown that Nobiletin can help regulate peripheral circadian rhythms [2]. It does so by activating unique receptors which are known to play a role in regulating circadian rhythms [13-16] which exist throughout the body [12].

Moreover, Nobiletin has also been shown to promote whole body health. In another pre-clinical study, Nobiletin was shown to regulate the expression of a certain set of genes. This particular set of genes help control the expression of other genes that control circadian rhythms in almost every cell in the body [3].

This, in turn, supports a healthy metabolism, as well as liver, kidney and brain health. It also helps maintain healthy blood pressure, cholesterol and triglyceride levels [17-20].

Warnings:

Keep out of reach of children.

Do not exceed recommended dose.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool and dry place.